Optimizing Drug Dosage Regimens Using Pharmacokinetic/Pharmacodynamic Modeling

Abstract

In the field of pharmacology, optimizing drug dosage regimens is essential for achieving therapeutic efficacy while minimizing adverse effects. Pharmacokinetic/pharmacodynamic (PK/PD) modeling has emerged as a powerful tool to guide dosage regimen optimization by integrating data on drug concentration-time profiles (pharmacokinetics) and drug effects (pharmacodynamics). This abstract provides an overview of the principles and applications of PK/PD modeling in drug dosage regimen optimization. First, the basic concepts of pharmacokinetics and pharmacodynamics are outlined, emphasizing their interplay in determining drug concentrations at the site of action and subsequent pharmacological effects. PK/PD modeling involves mathematical representation of these processes, enabling quantitative prediction of drug concentrations and responses over time.